Professor Huang is a behavioral neuroscientist (also referred to as a biopsychologist). His research interests are central post-stroke pain. Future studies will examine how the spinothalamocortical pathway and its specific neurons and molecular factors (e.g., BDNF and TrKb receptors and neuroinflammatory responses) regulate pain and its comorbid symptoms, which include major depression, anxiety disorders, and memory deficits. Recently, his research has primarily focused on drug addiction. In this area, his work examines the reward comparison hypothesis for morphine, amphetamine, and alcohol. His studies have produced a substantial amount of conflicting data that challenges the reward comparison hypothesis. He has introduced the paradoxical effect hypothesis of abused drugs to explain the reward and aversion effects of abused drugs as a controlling factor in drug addiction behaviors. His third investigation involves PTSD, a critical mental illness. He is analyzing the brain’s neural mechanisms for PTSD in an animal model. How the medial prefrontal cortex (mPFC) and amygdala are involved in PTSD symptoms and how the serotonin-specific reuptake inhibitor fluoxetine reduces PTSD symptoms in the brain are also being examined.